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This is the 7th of nine posts describing "Reasons for Skepticism" derived from scientific discovery, not from wishful speculations about the supernatural. These will be followed by several "Reconciliation Theories" for bridging the growing chasm between science and religion.
7. The evident futility of prayer. Adherents of most religions attempt to solicit favorable treatment from their deities through prayer. Thankfully, human sacrifice is no longer practiced as demonstration of piety in their solicitation of godly favors. Scientific studies of the efficacy of intercessory prayer have found uniformly that it has no effect on the intended beneficiary. Horrible events such as the Holocaust were surely the occasion of millions of desperate pleas to deities for merciful intercession, all for naught.
Unless one resorts to the cop-out explanation that "God works in mysterious ways," one can only conclude that god either is not listening, does not care, is powerless to intercede, or does not exist.