Life’s First Spark Re-Created in the Laboratory

Life’s First Spark Re-Created in the Laboratory
By Brandon Keim May 13, 2009 | 1:40 pm | Categories: Miscellaneous

A fundamental but elusive step in the early evolution of life on Earth has been replicated in a laboratory.

Researchers synthesized the basic ingredients of RNA, a molecule from which the simplest self-replicating structures are made. Until now, they couldn’t explain how these ingredients might have formed.

“It’s like molecular choreography, where the molecules choreograph their own behavior,” said organic chemist John Sutherland of the University of Manchester, co-author of a study in Nature Wednesday.

RNA is now found in living cells, where it carries information between genes and protein-manufacturing cellular components. Scientists think RNA existed early in Earth’s history, providing a necessary intermediate platform between pre-biotic chemicals and DNA, its double-stranded, more-stable descendant.

However, though researchers have been able to show how RNA’s component molecules, called ribonucleotides, could assemble into RNA, their many attempts to synthesize these ribonucleotides have failed. No matter how they combined the ingredients — a sugar, a phosphate, and one of four different nitrogenous molecules, or nucleobases — ribonucleotides just wouldn’t form.

Sutherland’s team took a different approach in what Harvard molecular biologist Jack Szostak called a “synthetic tour de force” in an accompanying commentary in Nature.

“By changing the way we mix the ingredients together, we managed to make ribonucleotides,” said Sutherland. “The chemistry works very effectively from simple precursors, and the conditions required are not distinct from what one might imagine took place on the early Earth.”


Like other would-be nucleotide synthesizers, Sutherland’s team included phosphate in their mix, but rather than adding it to sugars and nucleobases, they started with an array of even simpler molecules that were probably also in Earth’s primordial ooze.

They mixed the molecules in water, heated the solution, then allowed it to evaporate, leaving behind a residue of hybrid, half-sugar, half-nucleobase molecules. To this residue they again added water, heated it, allowed it evaporate, and then irradiated it.

At each stage of the cycle, the resulting molecules were more complex. At the final stage, Sutherland’s team added phosphate. “Remarkably, it transformed into the ribonucleotide!” said Sutherland.

According to Sutherland, these laboratory conditions resembled those of the life-originating “warm little pond” hypothesized by Charles Darwin if the pond “evaporated, got heated, and then it rained and the sun shone.”

Such conditions are plausible, and Szostak imagined the ongoing cycle of evaporation, heating and condensation providing “a kind of organic snow which could accumulate as a reservoir of material ready for the next step in RNA synthesis.”

Intriguingly, the precursor molecules used by Sutherland’s team have been identified in interstellar dust clouds and on meteorites.

“Ribonucleotides are simply an expression of the fundamental principles of organic chemistry,” said Sutherland. “They’re doing it unwittingly. The instructions for them to do it are inherent in the structure of the precursor materials. And if they can self-assemble so easily, perhaps they shouldn’t be viewed as complicated.”

See Also:

Forgotten Experiment May Explain Origins of Life
Organism Sets Mutation Speed Record, May Explain Life’s Origins

Proof That Meteors Could Have Sparked Life on Earth
A Theory of Evolution for Evolution

Humans and Aliens Might Share DNA Roots
Citations: Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions Matthew W. Powner, Beatrice Gerland & John D. Sutherland. Nature, Vol. 460, May 13, 2009.


“Systems chemistry on early Earth.” By Jack W. Szostak. Nature, Vol. 460, May 13, 2009.


Image: Universitat Pampeu Fabra

Brandon Keim’s Twitter stream and Del.icio.us feed; Wired Science on Facebook

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Comment by Lance Lockwood on May 15, 2009 at 8:04am
haha, after they told me that they "felt sorry for me" they went on to explain how unintelligent I was for believing in pseudo-science (buzz word) and circular logic. So I went on to explain how circular logic is believing in a deity, whose entire basis for existence relies on something that the deity itself inspired. When I was a christian I was never that abrasive...so I feel no pity for these "friends" of mine.
Comment by Jennifer W on May 15, 2009 at 6:23am
Wow, scientists never cease to amaze!
Comment by unholyroller on May 14, 2009 at 9:37pm
AAAAWWWWWSSSOOOOOME!!!!!!!!!
Comment by kimba on May 14, 2009 at 7:26pm
lol - naive for what? Celebrating a scientific advancement in the understanding of our origins? I hate the arrogance of those who would tell you what their god is going to do to you when they can't even explain what god is.
Comment by Lance Lockwood on May 14, 2009 at 7:05pm
I just posted this on my facebook and within an hour or so was called, naive, thick-headed, and condemned to hell, lol. I used to go to church with those people!
Comment by kimba on May 14, 2009 at 1:40pm
amazing but beautiful in its simplicity.
Comment by Justin Landherr on May 14, 2009 at 1:36pm
pure amazing
Comment by Lance Lockwood on May 14, 2009 at 12:27pm
Most Excellent!

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