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http://medicalxpress.com/news/2012-10-ketamine-defeats-chronic-depr...

 Apparently ketamine is beneficial for unipolar as well as bipolar depression and produces effects in hours rather than weeks like regular antidepressants. I found the stuff on synaptogenesis particularly interesting. 

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I wouldn't take it or recommend it, simply because of what Special K (not the cereal) can do to a person, esp neurologically.

I've seen the article. Hallucination is a serious side effect. However, as a treatment of last resort it sounds promising.

I've tried ketamine and it is horrible. It causes withdrawal from people around you then sleep. It is a horrible way to relieve depression. A much better medication is 6-APB.

From some one who partied on ketamin once in her early 20's, I don't recommend this.  The mind is already numbed enough in depression.  Proactive thinking is best.  I like the atheist Nathaniel Brandon's books, Undoing Depression, and Natural Prozac.  All three books to read in bed, since the depressed often rarely leave bed and they often can't afford a doctor.  Pulling Your Own Strings is a great one for women.  Depression is often anger at being a victim. 

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