Apparently ketamine is beneficial for unipolar as well as bipolar depression and produces effects in hours rather than weeks like regular antidepressants. I found the stuff on synaptogenesis particularly interesting.
I wouldn't take it or recommend it, simply because of what Special K (not the cereal) can do to a person, esp neurologically.
I've seen the article. Hallucination is a serious side effect. However, as a treatment of last resort it sounds promising.
I've tried ketamine and it is horrible. It causes withdrawal from people around you then sleep. It is a horrible way to relieve depression. A much better medication is 6-APB.
From some one who partied on ketamin once in her early 20's, I don't recommend this. The mind is already numbed enough in depression. Proactive thinking is best. I like the atheist Nathaniel Brandon's books, Undoing Depression, and Natural Prozac. All three books to read in bed, since the depressed often rarely leave bed and they often can't afford a doctor. Pulling Your Own Strings is a great one for women. Depression is often anger at being a victim.