I stopped talking to my sister for over a year because I just couldn't handle her bullshit any more. She has some severe psychiatric issues - she has just had a TBI diagnosed - and every conversation with her ended with me telling her that I didn't feel qualified to give her advice and she needed to talk to a therapist about her problems; she finally popped on me and stopped calling and I never called her back. Instead, I e-mailed her dd and got the details through her.
So now we're friends again and she's sworn to keep seeing a therapist, though I don't know if she'll ever be honest with anyone about her problems, so, the potential for another fallout lurks around every corner.
I have other sib's that I've completely cut out of my life, though, with no regrets.
I guess I posted this because I'm wondering if others in this age group have estranged family members (religious issues aside) and how often you re-establish contact with them.