Antidepressants can play a key role in alleviating painful conditions like osteoarthritis and may result in fewer side effects than traditionally prescribed drug regimes, such as anti-inflammatories and opioids, according to a perspective paper published online ahead of print publication by the International Journal of Clinical Practice.
"We believe that our analysis of these studies demonstrate that clinicians managing patients suffering from osteoarthritis should also consider prescribing adjunctive antidepressants that can effectively impact on central pain pathways" concludes Dr Leslie Citrome.
I had mixed results with Cymbalta. It worked very well for the pain, but the side effects (jitteriness, sweatiness, fatigue) kept getting worse. I tried a number of other meds in the same family but had to quit every time because of side effects.